I am fascinated by biology, complexity and chaos. Computer scientist and nuclear engineer by profession and training, I realized that software is inherently complex but the hardware we deal with is simple in the sense it’s mostly based on linear mathematics. (unless you are looking at simulating complex systems like neural networks, genetic programming). Until multi-threading is introduced, most software systems were too simple to mimic anything that’s remotely like the biological processes. Similarly most of nuclear physics is based on reductionism, approximation. The one exception to this is the theory of quantum mechanics. Quantum mechanics is the first theory in physics to accept there are limitations to our ability to view finer and finer details without the cause and effect interacting. What has been frustrating me with current physics is the attempt by theorists who are trying to reduce all of the physical phenomena into simple strings, bubbles etc. The true scientists in my opinion are the biologists who deal with complex systems and accept them as non-linear in nature. To whet my appetite and interest in this field, I read a lot of books and news on biology. I am especially interested in molecular biology, cell structures with emphasis on Telomeres and Telomerase. More recently I developed interest in Brain plasticity. Because of these interests, you will see my blogs reporting news on complex systems, telomeres, brain research, autism, stem cells etc.

If these broad areas are of interest to you and you would like me to cover some specific topics within those, please leave a comment here.

A little explanation of my choice for the name “RndSync”

Rnd stands for Random which is what biological process are driven by.

Sync – I was inspired by the book “Sync” by Steven Strogatz where he describes how the seemingly random events get synchronized to produce harmony. Emergence of sync is a very fascinating phenomenon – a byproduct of complex systems.


One Response to About

  1. Julian Lieb,M.D says:

    Julian Lieb, M.D

    The idea that antidepressants might be effective for cancer was first explored fifty years ago, and ample proof has emerged. More than one hundred published studies show that antidepressants kill cancer cells, inhibit their proliferation, augment chemotherapy, protect nonmalignant cells from ionizing radiation and chemotherapy toxicity, and convert multidrug resistant cells to sensitive. Antidepressants can arrest cancer even in advanced stages, occasionally eradicate it, and significantly extend life. To verify, access Medline or Pubmed, and enter “antidepressants” and “cancer.”

    Prostaglandins are nature’s universal signalers, self-regulating every physiological function in our bodies. When up-regulated prostaglandins cause many of our major disorders, the variations probably accounted for by our genes. In 1973, David Horrobin, a prolific prostaglandin researcher, was among those showing that lithium and antidepressants oppose prostaglandins, and in 1977, that prostaglandins regulate nucleic acids (DNA and RNA). Millie Hughes- Fulford and others followed by showing that prostaglandins regulate the synthesis, inhibition, and expression of genes. Later, Armato and Andreis showed that prostaglandins regulate the growth and differentiation of cells, and Goodlad cell division, when cancer is the accelerated division of abnormal cells. Earlier, Rashida Karmali showed that prostaglandins regulate the initiation, promotion, and spread of tumors. Other prostaglandin inhibiting agents such as aspirin and ibuprofen have also shown considerable promise in preventing, treating, and arresting cancer..

    It is the ethical and human right of physicians, patients, and the public, to be informed of medical research that offers hope for disorders bereft of hope. No one may modify, or subject the information to peer review. Dissemination of the innovation will remove a burden that society is unable to cope with. Safe, ethical, effective, available to all, outpatient prevention and treatment of cancer for a pittance, is not a bad deal. Millions dying at home, unable to afford treatment, transformed into people without pain, with energy, not wanting to die, and knowing that the monster has been tamed.

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    Levkovitz Y, Gil-Ad I, Zeidich E et al. Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome C, and caspase–3 involvement. J Mol Neurosci , 2005;27(1):29-42
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    Hisaoka K, Nishida A, Koda T, et al: Antidepressant drug treatments induce glial cell line-derivative neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells. J Neurochem 2001 Oct; 79(1): 25-34
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    Xia Z, Bergstrand A, DePierre JW, Nassberger L. The antidepressants imipramine, clomipramine and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase–3 activation. I Biochem Mol Toxicol. 1999; 13(6): 338-47
    Hsu SS, Huang CJ, Chen JS, et al. Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells. Basic Clin Pharmacol Toxicol. 2004 Sep; 95(3): 124-30
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    Pan CC, Cheng HH, and Huang CJ et al. The antidepressant mirtazapine induced cytosolic Ca2+ elevation and cytotoxicity in human osteosarcoma cells. Chin J Physiol. 2006 Dec 31; 49(6): 290-7
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    Walker AJ, Card T, Bates, TWE, Muir K. Tricyclic antidepressants and the incidence of certain cancers study using the GPRD. Br J Cancer 2010. Nov 16. [Epub ahead of print]

    Jovanovic D, et al Mianserin therapy in advanced lung cancer patients. 8th Central European Lung Cancer Conference. Vienna 2002. Internal Process Division, Monduzzi Editore 2002; 339-343
    All of this information is for educational purposes only. Any treatment decision should be arrived at in consultation with a .physician.


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